Q (haiku): Are TP53 mutations clinically actionable?

═ answer (success)
I need to clarify what you're asking, because "clinically actionable" has a specific meaning in oncology that cBioPortal can help you explore, but the answer depends on context.

**What cBioPortal can show you:**
- TP53 mutation frequency across cancer types and studies
- Which TP53 mutations are annotated as oncogenic drivers (via OncoKB)
- Clinical outcomes (survival, prognosis) associated with TP53 mutations in specific cohorts
- Treatment response data, if available in a study

**What I cannot tell you:**
- Whether TP53 mutations should drive treatment decisions in your clinic — that requires clinical judgment, guidelines (NCCN, ASCO, etc.), and your patient's specific context. I'm a research tool, not a doctor.

**To help you explore the data:**

Could you clarify what you'd like to know? For example:
1. **"Which TP53 mutations are annotated as oncogenic?"** — I can show you OncoKB driver annotations in a specific study or cancer type.
2. **"How common are TP53 mutations in [cancer type]?"** — I can query mutation frequency.
3. **"Do TP53 mutations predict survival outcomes in [study]?"** — I can retrieve survival data and link you to cBioPortal's Kaplan-Meier plots.
4. **"Are there drugs that target TP53-mutant cancers in cBioPortal?"** — I can search treatment data.

Which would be most useful?