Q (sonnet-5.5):
How can I find the TARGET information?
Do you mean the NCI TARGET program (Therapeutically Applicable Research to Generate Effective Treatments — pediatric cancer studies), or something else, such as studies on a particular drug target?
Continue this conversation: reply to the user's new message.
TARGET, the pediatric one
▶ list_studies
{
"search": "TARGET",
"limit": 50
}
◀ result
{"result":[{"cancer_study_identifier":"msk_ch_2023","name":"Cancer Therapy and Clonal Hematopoiesis (MSK, Blood Adv 2023)","type_of_cancer_id":"mixed","sample_count":42714,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=msk_ch_2023"},{"cancer_study_identifier":"msk_chord_2024","name":"MSK-CHORD (MSK, Nature 2024)","type_of_cancer_id":"mixed","sample_count":25040,"has_guide":true,"url":"https://www.cbioportal.org/study/summary?id=msk_chord_2024"},{"cancer_study_identifier":"msk_impact_2017","name":"MSK-IMPACT Clinical Sequencing Cohort (MSK, Nat Med 2017)","type_of_cancer_id":"mixed","sample_count":10945,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=msk_impact_2017"},{"cancer_study_identifier":"sarcoma_msk_2022","name":"Soft Tissue and Bone Sarcoma (MSK, Nat Commun 2022)","type_of_cancer_id":"soft_tissue","sample_count":7494,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=sarcoma_msk_2022"},{"cancer_study_identifier":"crc_msk_2026","name":"Colorectal Adenocarcinoma (MSK, 2026)","type_of_cancer_id":"read","sample_count":7237,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=crc_msk_2026"},{"cancer_study_identifier":"breast_msk_2026","name":"CCNE1 Amplifications in Breast Cancer (MSK, 2026)","type_of_cancer_id":"breast","sample_count":6318,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=breast_msk_2026"},{"cancer_study_identifier":"msk_ctdna_vte_2024","name":"MSK ctDNA Sequencing Cohort (MSK, Nature Medicine 2024)","type_of_cancer_id":"mixed","sample_count":5567,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=msk_ctdna_vte_2024"},{"cancer_study_identifier":"pancan_mimsi_msk_2024","name":"Mixed Tumors - MiMSI Cohort (MSK, Nat Commun 2024)","type_of_cancer_id":"mixed","sample_count":5033,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=pancan_mimsi_msk_2024"},{"cancer_study_identifier":"breast_msk_2025","name":"Breast Cancer (MSK, Nat Genet 2025)","type_of_cancer_id":"brca","sample_count":3879,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=breast_msk_2025"},{"cancer_study_identifier":"aml_target_gdc","name":"Acute Myeloid Leukemia (TARGET GDC, 2025)","type_of_cancer_id":"aml","sample_count":2766,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=aml_target_gdc"},{"cancer_study_identifier":"luad_mskcc_2023_met_organotropism","name":"Lung Adenocarcinoma Met Organotropism (MSK, Cancer Cell 2023)","type_of_cancer_id":"luad","sample_count":2653,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=luad_mskcc_2023_met_organotropism"},{"cancer_study_identifier":"nsclc_ctdx_msk_2022","name":"Metastatic Non-Small Cell Lung Cancer (MSK, Nature Medicine 2022)","type_of_cancer_id":"nsclc","sample_count":2621,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=nsclc_ctdx_msk_2022"},{"cancer_study_identifier":"brca_metabric","name":"Breast Cancer (MET … (9020 more chars)
▶ list_studies
{
"search": "TARGET GDC",
"limit": 20
}
◀ result
{"result":[{"cancer_study_identifier":"aml_target_gdc","name":"Acute Myeloid Leukemia (TARGET GDC, 2025)","type_of_cancer_id":"aml","sample_count":2766,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=aml_target_gdc"},{"cancer_study_identifier":"bll_target_gdc","name":"B-Lymphoblastic Leukemia/Lymphoma (TARGET GDC, 2025)","type_of_cancer_id":"bll","sample_count":989,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=bll_target_gdc"},{"cancer_study_identifier":"nbl_target_gdc","name":"Neuroblastoma (TARGET GDC, 2025)","type_of_cancer_id":"nbl","sample_count":533,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=nbl_target_gdc"},{"cancer_study_identifier":"alal_target_gdc","name":"Acute Leukemias of Ambiguous Lineage (TARGET GDC, 2025)","type_of_cancer_id":"alal","sample_count":251,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=alal_target_gdc"},{"cancer_study_identifier":"os_target_gdc","name":"Osteosarcoma (TARGET GDC, 2025)","type_of_cancer_id":"os","sample_count":159,"has_guide":true,"url":"https://www.cbioportal.org/study/summary?id=os_target_gdc"},{"cancer_study_identifier":"wt_target_gdc","name":"Wilms' Tumor (TARGET GDC, 2025)","type_of_cancer_id":"wt","sample_count":132,"has_guide":false,"url":"https://www.cbioportal.org/study/summary?id=wt_target_gdc"}]}
═ answer (success)
cBioPortal has two sets of pediatric TARGET studies. You can open any of them from the links below.
**TARGET GDC studies (2025, harmonized through the NCI Genomic Data Commons)**
| Cancer type | Study | Samples |
|---|---|---|
| Acute Myeloid Leukemia | [aml_target_gdc](https://www.cbioportal.org/study/summary?id=aml_target_gdc) | 2,766 |
| B-Lymphoblastic Leukemia/Lymphoma | [bll_target_gdc](https://www.cbioportal.org/study/summary?id=bll_target_gdc) | 989 |
| Neuroblastoma | [nbl_target_gdc](https://www.cbioportal.org/study/summary?id=nbl_target_gdc) | 533 |
| Acute Leukemias of Ambiguous Lineage | [alal_target_gdc](https://www.cbioportal.org/study/summary?id=alal_target_gdc) | 251 |
| Osteosarcoma | [os_target_gdc](https://www.cbioportal.org/study/summary?id=os_target_gdc) | 159 |
| Wilms' Tumor | [wt_target_gdc](https://www.cbioportal.org/study/summary?id=wt_target_gdc) | 132 |
**TARGET publication cohorts (2018)**
| Cancer type | Study | Samples |
|---|---|---|
| Pediatric Acute Lymphoid Leukemia, Phase II | [all_phase2_target_2018_pub](https://www.cbioportal.org/study/summary?id=all_phase2_target_2018_pub) | 1,978 |
| Pediatric Neuroblastoma | [nbl_target_2018_pub](https://www.cbioportal.org/study/summary?id=nbl_target_2018_pub) | 1,089 |
| Pediatric Acute Myeloid Leukemia | [aml_target_2018_pub](https://www.cbioportal.org/study/summary?id=aml_target_2018_pub) | 1,025 |
| Pediatric Wilms' Tumor | [wt_target_2018_pub](https://www.cbioportal.org/study/summary?id=wt_target_2018_pub) | 657 |
Some cancer types (AML, neuroblastoma, Wilms' tumor, and B-ALL/ALL) appear in both sets, so the samples may overlap. Don't add the counts across sets.
**How to explore them on cBioPortal**
- Open a study link to see its summary page. It has clinical charts (age, sex, diagnosis and others) and the mutation, copy-number and expression data available for that cohort.
- On the [portal home page](https://www.cbioportal.org), you can tick several TARGET studies together and query genes across them.
I can pull a specific number for you, such as mutation frequencies for a gene, age distributions or survival data. Tell me which cancer type and which question you have in mind. I can also generate a direct link to a filtered view or a gene query.