{
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  {
   "id": 42,
   "question": "In the TCGA PanCancer Atlas endometrial cancer study, what percentage of patients have co-occurring oncogenic mutations in both KRAS and NRAS?",
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   "track": "data",
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   "id": 62,
   "question": "In the TCGA Glioblastoma multiforme study compare the median patient age at diagnosis between patients with IDH1 R132H mutation and patients with wild-type IDH1.",
   "category": "Cohort & clinical counts",
   "track": "analysis",
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   "delta": -100.0,
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  {
   "id": 64,
   "question": "In TCGA PanCancer Atlas, which recurrent hotspot mutations occur almost exclusively in one cancer type?",
   "category": "Variants & hotspots",
   "track": "analysis",
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   "id": 68,
   "question": "What are the key genomic differences between lung adenocarcinomas and squamous cell carcinomas identified in the Pan-Lung Cancer TCGA study?",
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  {
   "id": 85,
   "question": "generate a oncoprint of kras, stk11, keap1, tp53 alterations stratified by smoking status in lung adenocarcinoma from the mskcc clincogenomic sequencing cohort. Please only select oncogenic somatic alterations and remove samples with unknown smoking status",
   "category": "Alteration frequency",
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  {
   "id": 86,
   "question": "what are the most common events in her2- breast cancer?",
   "category": "Alteration frequency",
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   "mismatch": [],
   "a": {
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  {
   "id": 96,
   "question": "Is KRAS G12C more aggressive than G12D?",
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  {
   "id": 102,
   "question": "calculate median expression of ceacam5, itgb6, muc2, tpgb and muc1 mRNA in pancreatic cancer",
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  {
   "id": 104,
   "question": "write me python code that can query the timeline files for msk-chord",
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   "id": 114,
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   "id": 17,
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   "id": 21,
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   "delta": 100.0,
   "latency_delta": -16.8785369588295,
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  },
  {
   "id": 73,
   "question": "What is the frequency of TP53 mutations in lung cancer?",
   "category": "Alteration frequency",
   "track": "data",
   "gradeable": true,
   "mismatch": [],
   "a": {
    "expected": 1,
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  {
   "id": 76,
   "question": "Are TP53 mutations clinically actionable?",
   "category": "Out of scope",
   "track": "out_of_scope",
   "gradeable": true,
   "mismatch": [],
   "a": {
    "expected": 1,
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   "delta": 100.0,
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  },
  {
   "id": 81,
   "question": "tell me about IDH1 mutations in glioma",
   "category": "Alteration frequency",
   "track": "data",
   "gradeable": true,
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   "a": {
    "expected": 1,
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    "attempt_rate": 100.0,
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  {
   "id": 83,
   "question": "Help me rank TCGA cancer studies based on median CD3 expression",
   "category": "Expression & multi-omics",
   "track": "analysis",
   "gradeable": true,
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   "b": {
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  {
   "id": 92,
   "question": "what is the most prevalent TP53 mutation in uterine cancer that is not a point mutation",
   "category": "Variants & hotspots",
   "track": "data",
   "gradeable": true,
   "mismatch": [],
   "a": {
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    "mean_llm_calls": 6,
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   "latency_delta": -3.9761287921573967,
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  {
   "id": 97,
   "question": "give me a contingency table with the number of lung cancer patients with EGFR and/or KRAS alterations",
   "category": "Co-occurrence & exclusivity",
   "track": "data",
   "gradeable": true,
   "mismatch": [],
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  {
   "id": 106,
   "question": "Which studies have RNA expression for renal cancer?",
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   "a": {
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  {
   "id": 109,
   "question": "I receive a report with the PIK3CA p.*1069Wext*3 mutation. Can you provide details of it",
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   "track": "data",
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  {
   "id": 116,
   "question": "What are the frequencies of different KRAS mutations in TCGA PanCan Lung Adenocarcinoma?",
   "category": "Variants & hotspots",
   "track": "navigation",
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   "mismatch": [],
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   "id": 117,
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   "latency_delta": -4.278418416855857,
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  },
  {
   "id": 71,
   "question": "What is the current and future support for storing and analyzing germline variants in cBioPortal, compared to other alternatives?",
   "category": "Out of scope",
   "track": "out_of_scope",
   "gradeable": true,
   "mismatch": [],
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  {
   "id": 72,
   "question": "Is there any study with a polygenic risk score?",
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    "expected": 1,
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    "expected": 1,
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  {
   "id": 74,
   "question": "What are the most mutated genes in lung cancer?",
   "category": "Alteration frequency",
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   "a": {
    "expected": 1,
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   "b": {
    "expected": 1,
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   },
   "delta": 0.0,
   "latency_delta": 2.6661171241430566,
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  },
  {
   "id": 75,
   "question": "How many patients have a shallow deletion for SMARCA4 in the POG study?",
   "category": "Patient & sample lookup",
   "track": "data",
   "gradeable": true,
   "mismatch": [],
   "a": {
    "expected": 1,
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    "expected": 1,
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  {
   "id": 77,
   "question": "can you show me the minerva viewer for the ohsu htan sample",
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   "track": "navigation",
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   "delta": 0.0,
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  {
   "id": 78,
   "question": "what's the best way to put clinical data into cbioportal?",
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   "mismatch": [],
   "a": {
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  {
   "id": 79,
   "question": "Can you please generate a survival curve for colorectal cancer patients based on the expression levels of IMPDH2?",
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   "mismatch": [],
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  {
   "id": 80,
   "question": "Is there a cohort of NSCLC patient samples that have Kras mutations, wild-type p53, and high expression levels of c-Myc?",
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   "track": "data",
   "gradeable": true,
   "mismatch": [],
   "a": {
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   "b": {
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   "delta": 0.0,
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  {
   "id": 82,
   "question": "How many GLASS patients developed hypermutation after TMZ treatment?",
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   "gradeable": true,
   "mismatch": [],
   "a": {
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  {
   "id": 84,
   "question": "Can you analyze thyroid hormone gene expression by diagnosis in the Pediatric Brain Tumor Atlas (PBTA, Provisional) cohort?",
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   "id": 88,
   "question": "what do idh1 mutations do?",
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   "id": 89,
   "question": "is there any imaging data?",
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   "id": 90,
   "question": "show me the distribution of mutations in the tert promoter across cancer types",
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   "id": 93,
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   "question": "Can you think of any flaws in the methodology used in the MSK-CHORD paper (Jee et al., Nature 2024)?",
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   "question": "Can you help me write a production-ready Python script using Bokeh to build an interactive clinicogenomic dashboard to analyzing the MSK-CHORD dataset? I have some specific requirements I can give you",
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   "id": 100,
   "question": "How many samples are there that have any of these mutations in SEPHS1: p.Arg371Trp, p.Arg371Gln, p.Arg371Gly?",
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   "track": "data",
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   "id": 101,
   "question": "List the top 20 mutated genes in study nbl_msk_2023.",
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   "id": 103,
   "question": "in salivary cancer (adenoid cystic carcinoma), what are the expected drivers ? Classify them by actionability. What about BCOR mutations, either somatic or germline ?",
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  {
   "id": 105,
   "question": "list the portal studies for pediatric cancers that were published in the last 5 years",
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   "id": 107,
   "question": "What kind of cancer are there in the database?",
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  {
   "id": 108,
   "question": "Can you find a study that I may emulate that has a data_clinical_outcomes.txt file and associated meta file to interogate",
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  {
   "id": 110,
   "question": "Can you explore the difference in mutation frequency between left-sided and right-sided CRC?",
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   "id": 111,
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   "id": 112,
   "question": "Which cBioPortal studies include lung adenocarcinoma samples with mutation and copy-number data?",
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   "id": 113,
   "question": "In lower grade glioma, are there genes which are overexpressed in any of the molecular subtypes?",
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   "id": 115,
   "question": "Are there DNA methylation differences between lower grade glioma molecular subtypes?",
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   "id": 118,
   "question": "In TCGA lower grade glioma, show me IDH1 mRNA expression by IDH1 mutation status.",
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  {
   "id": 119,
   "question": "In lower grade glioma, how do outcomes differ for IDH1 altered vs EGFR altered patients?",
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   "id": 120,
   "question": "is there a relationship between cic mutation and 19q del in lgg?",
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   "id": 121,
   "question": "In TCGA lower grade glioma, show me samples with EGFR gains.",
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   "id": 122,
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   "id": 124,
   "question": "show me EGFR expression across cancer types",
   "category": "Expression & multi-omics",
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   "id": 125,
   "question": "show me point mutations in EGFR in lung cancer",
   "category": "Variants & hotspots",
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   "a": {
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   "id": 126,
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   "id": 127,
   "question": "show me gbm with mgmt hypermethylation",
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   "id": 128,
   "question": "Is there a lower grade glioma study with race data?",
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   "id": 129,
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   "id": 130,
   "question": "are there different outcomes for idh1 mutant vs egfr amp in lgg?",
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   "id": 131,
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   "id": 132,
   "question": "Create an OncoPrint with a merged track for the EGFR family genes (EGFR, ERBB2, ERBB3, ERBB4) across TCGA PanCancer Atlas studies.",
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  {
   "id": 133,
   "question": "What are the EGFR mutation frequencies across cancer types in the MSK-IMPACT 50K study?",
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  {
   "id": 134,
   "question": "compare egfr mutations between lung and brain cancer",
   "category": "Alteration frequency",
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  {
   "id": 136,
   "question": "In the TCGA Breast Cancer study, do TP53 mutations and high MYC expression co-occur or are they mutually exclusive?",
   "category": "Co-occurrence & exclusivity",
   "track": "analysis",
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  {
   "id": 137,
   "question": "In the TCGA Glioblastoma multiforme study (gbm_tcga_pan_can_atlas_2018), how many patients have an IDH1 R132H mutation and how many are IDH1 wild-type.",
   "category": "Cohort & clinical counts",
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   "id": 138,
   "question": "show me all KRAS mutations in colorectal cancer that are not at position 12",
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   "id": 139,
   "question": "show me cholangio with idh1 mutations other than r132",
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   "id": 140,
   "question": "what's the frequency of different idh1 mutations in glioma vs cholangio vs chndrosarcoma? Give me a link to compare the frequency of the specific IDH1 mutations in those cancer types.",
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   "track": "navigation",
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  {
   "id": 142,
   "question": "Give me an OncoPrint for RTK genes in lung cancer, limited to driver events.",
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   "track": "navigation",
   "gradeable": true,
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  {
   "id": 144,
   "question": "are lung carcinosarcomas associated with BRIP1 mutations?",
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   "mismatch": [],
   "a": {
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   "b": {
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 }
}
